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In the world of tablet manufacturing, the phenomenon of “tablet sticking” has been a persistent challenge, often leading to production delays, quality issues, and increased costs. The science behind tablet sticking is complex, but understanding it is essential for pharmaceutical and nutraceutical companies seeking to optimize their production processes and ensure product quality. At Natoli Scientific, we not only comprehend the intricacies of this issue but have also become a trusted authority in providing solutions to overcome it.

“A well-designed tablet can ensure solid tablet quality, maximize tablet production, enhance the product lifecycle, and create easy recognition, which builds brand equity and incorporates brand authentication.” – Natoli Scientific

The Tablet Sticking Conundrum

Tablet sticking refers to the phenomenon where tablet granules adhere to the surface of the punch face during the compression process. It’s a challenge that can plague pharmaceutical and nutraceutical companies, causing a cascade of production issues such as reduced yields, increased machine downtime, and tablet defects. But what’s the science behind this persistent problem?

Sticking often occurs due to the interplay of various factors, including material properties, tooling design, and the tablet compression process itself. As our Director at Natoli Scientific, Robert Sedlock, explains, “In the intricate world of tablet compression, shaped tooling consistently stands out, primarily due to the comprehensive, incisive data it discloses about your tablet formulation during the compression process. Its aptitude for constructing complex shapes and applying diverse forces provides a matchless insight into the distinctive properties and responses of your formulation throughout compression.”

Our Comprehensive Approach

At Natoli Scientific, we are committed to unraveling the science behind tablet sticking. Our extensive expertise and state-of-the-art equipment enable us to provide unparalleled insights and practical solutions to overcome this challenge.

“Understanding that if the final tablet shape varies from what is tested, the collected data becomes solely applicable to those unique conditions is fundamental. Simply put, it’s the science of the process.” – Natoli Scientific

We offer services ranging from preformulation support to help understand material properties to formulation troubleshooting and even manufacturing scale-up. We are your partner in ensuring that your tablet manufacturing process is optimized and compliant.

“When it comes to preformulation needs of solid dosage forms, Natoli Scientific is a natural choice to ensure your product meets its Quality Target Product Profile (QTPP). We provide raw material characterization, powder flow analysis, and other essential tests that are critical for robust formulation development.” – Natoli Scientific

Our team of experts collaborates with academic institutions globally, sharing knowledge and conducting research to drive innovation in the tablet manufacturing industry. We are proud to work alongside esteemed institutions such as Drexel University, the University of Mississippi, and academic partners like Dr. Rahul Haware, Dr. Devang Patel, and Mr. John Sturgis, among others, to generate new knowledge.

“We are collaborating with academic experts from various disciplines to generate new knowledge. This collaborative approach not only advances the science behind tablet manufacturing but also showcases our in-house expertise as we partner with renowned authors and experts.” – Natoli Scientific

Natoli Scientific: Your Sticking Solution

If you’re facing the challenge of tablet sticking, you’re not alone. It’s a complex issue, but with the right knowledge and expertise, it can be solved. At Natoli Scientific, we aim to be your trusted partner in this journey. We provide you with the tools, insights, and solutions you need to optimize your tablet manufacturing processes.

“Natoli Scientific is armed with a dynamic team of experts who are dedicated to providing on-demand pragmatic solutions to save time and cost in the production cycle. Because saving in the product development and manufacturing is serving to patients and humanity.” – Natoli Scientific

By collaborating with us, you’re not just addressing the issue of tablet sticking; you’re also making a commitment to improve the quality, efficiency, and reliability of your tablet manufacturing processes.

Join us in our mission to explore the science behind tablet sticking, unlock innovative solutions, and enhance the future of tablet manufacturing. Follow Natoli Scientific on LinkedIn to stay updated with the latest advancements in the industry and be part of a community that values quality, precision, and scientific excellence.

“At Natoli Scientific, we believe in the transformative impact our expert scientific services can have on your tablet manufacturing processes and bottom line. Your challenge is our solution.” – Natoli Scientific

Join us in exploring the science behind tablet sticking. Together, we can unlock the potential of your tablet production and ensure the highest quality in every tablet you make.

Follow Natoli Scientific on LinkedIn and be part of our journey towards excellence in tablet manufacturing.


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