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Capabilities & Services

Natoli Scientific is 14,000 sq. ft. facility located at Telford, PA. We are equipped with the ‘state-of-the-art’ equipment required for your preformulation studies, formulation development, formulation troubleshooting, and start-up manufacturing needs.

Our dedicated scientist team has expertise in handling dynamic and complex issues of powder mechanics. Natoli Scientific’s on-site analytical capabilities expand from basic to advanced powder micrometrics characterization, Compaction simulation or emulation, USP <1062>, solid orals quality control testing, and informal and ICH stability studies.

Analytical Capabilities

Analytical Service Spectrum Graphic

On-Site Analytical Capabilities:

Powder Micromeritics:

  • Density Measurements:
    • Bulk and Tapped density measurement
    • Helium pycnometer
  • Granule Characterization:
    • Particle size and distribution measurement (Sieve analysis: d10, d50, d90)
    • Moisture analyzer (Loss on drying)
  • Powder Flow Measurements:
    • FT4 powder rheometer
    • Angle of repose

USP <1062>:

  • Basic Compression Studies [USP<1062>]:
    • Natoli RD 10

Compaction Simulation/Emulation:

  • Compaction Testing Characterization:
  • Advanced Compression Studies:
    • Presster compaction emulator

Batch/Lot Testing for Release:

  • Tablet breaking force (hardness) tester
  • Tablet friability testing
  • Tablet disintegration testing
  • Tablet dissolution testing

Analytical Method Development and Validation:

  • HPLC method for API characterization and quantification
  • Developing discriminatory dissolution media
  • Tablet dissolution testing
    • pH meter
    • Agilent HPLC

Stability Studies:

  • Informal stability studies
  • Forced degradation studies
  • Accelerated stability studies
  • Beyond use or expiration date
    • Two dedicated ICH stability chambers (Humidity and Temperature controlled)

Additional Analytical Capabilities:

We offer various highly advanced analytical testing for complete pharmaceutical material characterization (API and excipients) with our partner labs.
  • Rigaku Smartlab Full Featured Laboratory System Powder   X-Ray Diffractometer
  • Tablet CT-Scan Topography
  • Q2000 high sensitivity DSC Thermal Analysis Instrument
  • Q5000 high sensitivity TGA Thermal Analysis Instrument
  • Q5000 SA Dynamic Moisture Sorption Analyzer
  • Malvern Mastersizer 3000 with Dry Powder Feeder Particle  Sizer (d10, d50, d90)
  • Texture Analyzer
  • Karl Fisher Titration (Water content)
  • PerkinElmer® ATR-FTIR
  • Zetasizer Nano ZS
  • Shimadzu UV-1240 UV Spectrophotometer
One Stop Shop for Your Analytical Needs

Lab-Scale Manufacturing Capabilities:


  • V-blender (2-quart, 4-quart, 1 cu.ft., 5 cu.ft.)

Wet Granulation:

  • High shear granulator
    (Manufacturer: Diosna, Model: P 1-6)
  • Low shear granulator
  • Fluid bed granulator
    (Manufacturer: Diosna, Model: Minilab RC)

Dry Granulation:

  • Roller compactor


  • Buchi


  • (Manufacturer: Frewitt)
  • Oscillation mill (Model: Oscillowitt-Lab)
  • Hammer mill (Model: Hammerwitt-Lab)
  • Co-mill (Model: Coniwitt-Lab)

Tablet Manufacturing:

  • Natoli NP-RD 30 (4-station; B and D-tooling) with AIM Data Acquisition System

Tablet Coating:

  • Tablet coater (Manufacturer: Diosna, Model: Minilab RC)
  • Fluid bed coater for Minitabs, and Pellets (Manufacturer: Diosna, Model: Minilab RC)

Start-Up Manufacturing Capabilities:

  • V-blender (20 ft)
Dry Granulation:
  • Roller compactor (Vector)
  • Natoli NP-400 (22-stations)
  • MarkIIa 37 Station Double-Sided
Manufacturing Graphic
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Call us +1 636-926-8900